NO DR NPDR PDR ETDRS monocular severity scale1 Binocular person-level
scale1 Very mild Mild Moderate Moderately severe Severe or very severe Mild Patients graded by a central reading center based on fundus photography. DR, diabetic retinopathy; DRSS, Diabetic Retinopathy Severity Scale; ETDRS, Early
Treatment Diabetic Retinopathy Study; NPDR, non-proliferative diabetic retinopathy; PDR, proliferative diabetic retinopathy. 1. Chew EY, et al. N Engl J Med. 2010;363:233-44. Binocular DRSS is a Validated and Well-Established Scale to
Evaluate Systemic Therapies for Diabetic Retinopathy 5 10 20 35 43 47 53 60-61 65 71+ Moderate Severe 2,3 4,5 6,7 8,9 10,11 12,13 14,15 16,17+ 1 ≥ 3 step worsening on the binocular DRSS is considered clinically
meaningful